More Pain for Arthritis Drugs

Joe Saunders
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Posted by Joe SaundersSeptember 12, 2008 1:15 PM
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First it was Vioxx and Celebrex linked to an increase in heart attacks and strokes. Now, arthritis drugs Humira, Cimzia, Enbrel and Remicade are drawing FDA attention for a potential fungal infection known as histoplasmosis. The drugs work by suppressing the immune system which can lead to a dangerous, possibly deadly fungal infection. The US FDA is requiring the makers of the drugs to strengthen their warning labels.

Of 240 cases reported, 45 people have died from the fungal infection. The fungal infection is not necessarily easy to diagnose and some doctors have missed the diagnosis resulting in serious illness even death. According to the NY Times, the 4 drugs have also been linked to cancer in young patients.

None of this is good news for the drug makers. Humira is sold by Abbott Laboratories; Cimzia by UCB; Enbrel by Amgen Inc. and Wyeth; and Remicade by Centocor, a unit of Johnson & Johnson and Schering-Plough Inc

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